Technology
Stem cell renewal and maintenance and tissue regeneration are critical for normal health and well-being. Wnt pathway interactions are crucial to maintenance of these processes. Ankasa is the first to produce human Wnt proteins in a manufacturing setting suitable for use in humans.
Our first clinical approach will be the demonstration of improved outcomes after spinal fusion surgeries. Our product has expansion opportunities to other bone reconstructive procedures including osseointegration of dental and orthopedic implants (knee and hip replacements), fracture repair, total joint arthroplasty revisions, and others.
ART352-L:
Regenerative Medicine for Better Bone Formation
Large Growing
Market(s)
Novel Product with
Compelling Data
Robust Pipeline
Potential
De-Risked Phase 2
Opportunity
Proven Executive
Leadership
Spinal fusion:
$5B+ US/$3B ex-US market
$9.5B US market
- Liposomally delivered rhWnt3 protein activates resident stem cells to osteogenic phenotype.
- Potential for superior bone formation vs. autograft
- Goal is more rapid fusion, higher fusion rates and durability
Scientifically proven platform for pipeline expansion to arthroplasty, fracture and dental applications
GMP manufacturing complete
ART352-L:
Regenerative Medicine for Better BoneFormation
Large Growing
Market(s)
Novel Product with
Compelling Data
Robust Pipeline
Potential
De-Risked Phase 2
Opportunity
Proven Executive
Leadership
Spinal fusion:
$5B+ US/$3B ex-US market
- Goal is more rapid fusion, higher fusion rates and durability
Total join arthroplasty (hip/knee):
$9.5B US market
Scientifically proven platform for pipeline expansion to arthroplasty, fracture, and dental applications
- Liposomally delivered rhWnt3 protein activates resident stem cells to osteogenic phenotype.
- Potential for superior bone formation vs autograft
GMP manufacturing complete
Unmet medical need:
Autograft efficacy declines with age.
In patients >50, autograft becomes unreliable. This functional decline can be attributed to aging skeletal stem cells & insufficient growth factors.
ART352-L
addresses this deficit
Ankasa’s proprietary Wnt3 protein therapeutic activates skeletal stem cells and accelerates bone regeneration in animal models of spinal fusion, segmental defects and osseointegration.
Pipeline
Multiple value inflection points through continued advancement to additional indications
+ Internal Expansion
- Lumbar spine
+ Spine Expansion
- Cervical
- Total Joint Arthoplasty
- Dental
- cartilage and tendon repair
Pipeline
Multiple value inflection points through continued advancement to additional indications
+ Internal Expansion
Lumbar spine
+ Spine Expansion
Cervical
+ Indication Expansion
Total Joint Arthoplasty
Dental
+ Tissue Type Expansion
Carttiledge and tendon repair?
Pipeline
Leveraging established GMP manufacturing, critical scientific know- how and clinical development expertise
Multiple value inflection points through continued advancement to additional indications
+ Internal Expansion
Lumbar spine
+ Spine Expansion
Cervical
+ Indication Expansion
Total Join Arthoplasty
Dental
+ Tissue Type Expansion
Carttiledge and tendor repair?
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